Prof. Li’s current research efforts are to develop Green Chemistry for organic synthesis based upon innovative and fundamentally new chemical reactions that will defy conventional reactivities and possess high “atom-efficiency”. Well-known research developed by Prof. Li include a wide range of Grignard-type reactions in water, transition-metal catalysis in air and water, alkyne–aldehyde–amine coupling reaction (A3-coupling), and the Cross-Dehydrogenative Coupling (CDC) reactions, biomass conversions and non-oxidative catalytic conversion of methane to hydrogen and benzene among others. His research has been cited widely in the literature (>38,000 times, h-index = 96). He was elected as a Fellow of the Royal Society of Chemistry (2007), the Royal Society of Canada (Academy of Science) (2012), the AAAS (2012), the CIC (2013), the ACS (2015), and TWAS (2016). He has published >400 peer-reviewed articles and has given >400 plenary/keynote/invited lectures.